Fluorene derivative

Details Fluorene derivative Fluorene derivative

C - Chemistry, Metallurgy

07

C

C07C 279/22 (2006.01) A61K 31/166 (2006.01) A61K 31/343 (2006.01) A61K 31/351 (2006.01) A61K 31/352 (2006.01) A61K 31/357 (2006.01) A61K 31/385 (2006.01) A61K 31/41 (2006.01) A61K 31/4168 (2006.01) A61K 31/4196 (2006.01) A61K 31/421 (2006.01) A61K 31/426 (2006.01) A61K 31/438 (2006.01) A61P 25/06 (2006.01) A61P 43/00 (2006.01) C07D 221/20 (2006.01) C07D 233/88 (2006.01) C07D 249/08 (2006.01) C07D 257/04 (2006.01) C07D 263/28 (2006.01) C07D 277/18 (2006.01) C07D 277/28 (2006.01) C07D 307/94 (2006.01) C07D 30

Patent

CA 2537079

A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly for 5-HT2B receptor and 5-HT7 receptor, among serotonin receptor subtypes, and exhibiting an excellent pharmacological effect compared with a conventional compound having an antagonistic activity to only one of the 5- HT2B receptor and 5-HT7 receptor. Thus, it is useful as a highly efficacious and safe preventive for migraine.

Un nouveau fluorène caractérisé en ce qu~il présente un squelette fluorène auquel un groupe fonctionnel tel qu~un groupe guanidino est attaché via un groupe carbonyle, ou son sel. Ce composé a l~avantage d~avoir une haute affinité en particulier pour le récepteur de 5-HT¿2B? et le récepteur de 5-HT¿7?, parmi les sous-types du récepteur de sérotonine, et de présenter un excellent effet pharmacologique en comparaison avec un composé conventionnel ayant une activité antagoniste envers uniquement un du récepteur de 5-HT¿2B ?et le récepteur de 5-HT¿7?. Ainsi, il est utile en tant que composé préventif hautement efficace et sans danger pour la migraine.

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