Fluorescence-based optical sensor for detection of...

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150/19, 73/51.5

G01N 21/64 (2006.01) G01N 33/15 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2019066

FLUORESCENCE-BASED OPTICAL SENSOR FOR DETECTION OF LIPID-SOLUBLE ANALYTES Abstract of the Disclosure A sensor, probe, system and method for detecting the presence of or concentration of lipid-soluble analytes such as anesthetics, which involve the use of fluorophore-containing lipid layers or similar amphiphilic structures as the sensor. The lipid layer is constituted such that it has a phase transition temperature equal to or close to the temperature at which the measurement of the analyte is conducted. Partitioning of a suitable analyte into the lipid layer results in a phase change which is then reflected in a change in a fluorescence characteristic, such as a shift in the wavelength of maximum intensity of fluorescence, of the fluorophore, in proportion to the amount of analyte.

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