Fluorescence imaging system

Details Fluorescence imaging system Fluorescence imaging system

H - Electricity

04

N

350/32

H04N 7/18 (2006.01) G01N 21/64 (2006.01) G01J 3/12 (2006.01)

Patent

CA 1265232

APPLICANT: HIGHTECH NETWORK SCI AB TITLE: A FLUORESCENCE IMAGING SYSTEM ABSTRACT OF THE DISCLOSURE A fluorescence imaging system includes a light source, preferably a pulsated laser, which irradiates an object, optionally via further optical components, so as to induce fluorescence radiation in the object. This radiation images the object on a detector plane. In accordance with the invention there is provided a beam-splitting system, such that the fluorescent object is reproduced in the form of at least three, and preferably four separate and mutually adjacent images. A selected filter is placed in each of the paths of these partial light beams. The detector plane has a plurality of image-point detectors each of which produces a respective electric signal, so that there is obtained for each image point at least three, and preferably four intensity signals recorded for a respective frequency band determined by respective filters. These signals are processed mathematically to provide a weighted signal value, which may be dimen- sionless. These weighted image-point values are repro- duced, for example on a video-monitor, which makes possible fluorescence reproduction rich in contrast and free from disturbances with respect to spectral signa- tures. One example of the use to which the invention can be put is the detection of cancer cells to which a fluo- rescence signature has been imparted with the aid of HPD.

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