Fluorescent assay and compounds useful therein

Details Fluorescent assay and compounds useful therein Fluorescent assay and compounds useful therein

C - Chemistry, Metallurgy

07

D

167/43, 260/179.

C07D 471/04 (2006.01) C07D 471/14 (2006.01) G01N 33/533 (2006.01)

Patent

CA 1254829

- 59 - Abstract of the Disclosure 1,10-phenanthroline-2,9-dicarboxylic acid and novel derivatives thereof such as 4,7-diphenyl-1,10-phenanthroline-2,9-dicar- boxylic acid and 4,5,9,14-tetraaza-(1,2,3,4)-dibenzanthracene- 3,5-dicarboxylic acid can be coupled to proteins through coup- ling groups to form conjugates which form highly fluorescent chelates in the presence of lanthanide salts. Derivatives of the above acids reactive toward proteins can be readily manu- factured by relatively simple synthetic routes, and are useful in fluorescent immunoassay.

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