C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/06 (2006.01) A61B 1/04 (2006.01) A61B 5/00 (2006.01) A61B 10/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C09K 11/00 (2006.01) C09K 11/06 (2006.01) G01N 33/574 (2006.01) G02B 21/00 (2006.01) A61B 1/313 (2006.01) A61B 19/00 (2006.01) G01N 21/64 (2006.01)
Patent
CA 2441146
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
La présente invention concerne des cobalamines fluorescentes et les utilisations de ces composés. Cette invention concerne en particulier des cobalamines fluorescentes contenant un composé fluorescent, phosphorescent, luminescent ou produisant de la lumière, lié par covalence à la cobalamine. Ces cobalamines fluorescentes peuvent être utilisées en tant que marqueurs diagnostiques et prognostiques de manière (a) à établir une distinction entre des cellules et tissus cancéreux et des cellules et tissus sains, par l'identification de ganglions lymphatiques renfermant des cellules cancéreuses, et (b) à determiner si un individu réagira de façon positive à une chimiothérapie utilisant des bioconjugués pour thérapie à la cobalamine.
Cannon Michelle J.
Grissom Charles B.
Mcgreevy James
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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