C - Chemistry – Metallurgy – 09 – K
Patent
C - Chemistry, Metallurgy
09
K
C09K 11/06 (2006.01) A61K 49/00 (2006.01) C07F 9/6561 (2006.01) C07H 23/00 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) C07H 19/052 (2006.01)
Patent
CA 2387503
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly. this in- vention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
La présente invention concerne des cobalamines fluorescentes et les utilisations de ces composés. En particulier, l'invention concerne des cobalamines fluorescentes contenant un composé fluorescent, phosphorescent, luminescent ou produisant de la lumière, lié par covalence à la cobalamine. Ces cobalamines fluorescentes peuvent être utilisées en tant que marqueurs diagnostiques et pronostiques afin de distinguer (a) des cellules et tissus cancéreux des cellules et tissus sains, et de déterminer (b) si un individu réagira positivement à une chimiothérapie utilisant des bioconjugués de cobalamine thérapeutiques.
Bentz Joel S.
Grissom Charles B.
Mcgreevy James
West Frederick G.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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