Fluorescent imaging agents

Details Fluorescent imaging agents Fluorescent imaging agents

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/04 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 5/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2749108

Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

L'invention concerne une famille d'agents d'imagerie ayant subi une extinction intramoléculaire pour une utilisation en imagerie in vivo et in vitro qui contiennent au moins un oligopeptide enzymatiquement clivable et deux fluorophores ou un fluorophore et un extincteur. Lorsqu'il est soumis à un clivage protéolytique, au moins un fluorophore est non éteint et devient capable de produire un signal fluorescent au moment d'une excitation avec une lumière de longueur d'onde appropriée. Des procédés d'imagerie in vivo et in vitro utilisant de tels agents d'imagerie sont également prévus.

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