Fluorescent imaging with substituted cyanine dyes

Details Fluorescent imaging with substituted cyanine dyes Fluorescent imaging with substituted cyanine dyes

A - Human Necessities

61

F

A61F 2/44 (2006.01) C09B 23/00 (2006.01) C09B 23/08 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2758952

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula (I) are presented: (I). wherein Q is a portion of a polymethine bridge selected from the group consisting of: (a) and (b). Also included are bioconjugates of the compounds of For-mula (I), methods of labeling biomolecules with the com-pounds, and methods of imaging.

La présente invention concerne des composés et des procédés qui sont utiles pour l'imagerie non invasive dans la gamme spectrale de l'infrarouge proche. Les composés de cyanine de formule (I) sont présentés : (I) dans laquelle Q est une partie d'un pont polyméthine choisie dans le groupe constitué de : (a) et (b). La présente invention concerne en outre des bioconjugués des composés de formule (I), des procédés de marquage de biomolécules avec les composés, et des procédés d'imagerie.

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