C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 61/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2665165
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
La présente invention concerne des procédés et des compositions comprenant un multichromophore et/ou un complexe multichromophore permettant d'identifier une biomolécule cible. Une biomolécule détectrice, par exemple un anticorps, peut être liée par liaison covalente au multichromophore. En outre, un chromophore signal peut être lié par liaison covalente au multichromophore. Le dispositif est tel que le chromophore signal peut recevoir de l'énergie du multichromophore suite à l'excitation de ce dernier. Comme la biomolécule détectrice est capable d'interagir avec la biomolécule cible, le multichromophore et/ou le complexe multichromophore peut fournir des signaux de détection renforcés concernant une biomolécule cible.
Fu Tsu-Ju
Gaylord Brent S.
Hong Janice W.
Sun Cheng Jun
Gowling Lafleur Henderson Llp
Sirigen Inc.
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