Fluorescent nanoparticle compositions, methods, and devices

Details Fluorescent nanoparticle compositions, methods, and devices Fluorescent nanoparticle compositions, methods, and devices

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 1/05 (2006.01) A61B 1/313 (2006.01) A61K 41/00 (2006.01)

Patent

CA 2683635

Various compositions, methods, and devices are provided that use fluorescent nanoparticles, which can function as markers, indicators, and light sources. The fluorescent nanoparticles can be formed from a fluorophore core surrounded by a biocompatible shell, such as a silica shell. In one embodiment, the fluorescent nanoparticles can be delivered to tissue to mark the tissue, enable identification and location of the tissue, and/or illuminate an area surrounding the tissue. In another embodiment, the fluorescent nanoparticles can be used on a device or implant to locate the device or implant in the body, indicate an orientation of the device or implant, and/or illuminate an area surrounding the device or implant. The fluorescent nanoparticles can also be used to provide a therapeutic effect.

L'invention concerne divers compositions, procédés et dispositifs qui utilisent des nanoparticules fluorescentes, pouvant servir de marqueurs, d'indicateurs et de sources de lumière. Les nanoparticules fluorescentes peuvent être formées à partir d'un noyau fluorophore entouré d'une enveloppe biocompatible, telle qu'une enveloppe de silice. Dans un mode de réalisation, les nanoparticules fluorescentes peuvent être délivrées à un tissu pour marquer le tissu, permettre l'identification et l'emplacement du tissu, et/ou éclairer une zone entourant le tissu. Dans un autre mode de réalisation, les nanoparticules fluorescentes peuvent être utilisées sur un dispositif ou un implant pour localiser le dispositif ou l'implant dans le corps, indiquer une orientation du dispositif ou de l'implant et/ou éclairer une zone entourant le dispositif ou l'implant. Les nanoparticules fluorescentes peuvent être également utilisées pour fournir un effet thérapeutique.

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