Fluorescent probe for zinc

Details Fluorescent probe for zinc Fluorescent probe for zinc

C - Chemistry, Metallurgy

07

D

C07D 311/82 (2006.01) C07D 405/14 (2006.01) C07D 493/10 (2006.01) C09B 11/24 (2006.01) C09B 11/28 (2006.01) G01N 21/77 (2006.01)

Patent

CA 2401359

Compounds of the general formula (IA) or salts thereof, useful as fluorescent probes for the quantitation of zinc: (IA) wherein R1 and R2 are each hydrogen or a group of the general formula (A) (wherein X1, X2, X3 and X4 are each hydrogen, alkyl, 2-pyridylmethyl, or an amino-protective group; and m and n are each 0 or 1), with the proviso that both R1 and R2 must not be hydrogen; R3 and R4 are each hydrogen or halogeno; R5 and R6 are each hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl; and R7 is hydrogen or alkyl.

La présente invention concerne des composés de formule générale (IA) ou de leurs sels, utiles en tant que sondes fluorescentes pour la quantification du zinc dans laquelle: R?1¿ et R?2¿ représentent l'hydrogène ou un groupe de formule générale (A) (dans laquelle X?1¿, X?2¿, X?3¿ et X?4¿ représentent l'hydrogène, un radical alkyle, 2-pyridyleméthyle, ou amino-protégé; et m et n représentent 0 ou 1), à condition que R?1¿ et R?2¿ à la fois ne représentent pas l'oxygène; R?3¿ et R?4¿ représentent l'hydrogène or halogène; R?5¿ et R?6¿ représentent chacun l'hydrogène, alkylcarbonyle, ou alkylcarbonylméthyle; et R?7¿ représente l'hydrogène ou alkyle.

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