C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/435 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2663249
Protein probes and methods for measuring real-time changes in intracellular superoxide formation are provided. The probes include superoxide sensitive variants of yellow fluorescent and green fluorescent proteins. The probes, or nucleic acids encoding the probes, may be delivered to cells or organisms. Changes in the fluorescence of the probes may then be detected using standard real-time fluoroscopy techniques.
La présente invention concerne des sondes de protéines ainsi que des procédés permettant de mesurer les changements intervenant en temps réel dans la formation intracellulaire de superoxyde. Les sondes comprennent des variantes de protéines fluorescentes jaunes et fluorescentes vertes, sensibles au superoxyde. Les sondes, ou des acides nucléiques codant les sondes, peuvent être distribuées vers des cellules ou des organismes. Les changements de fluorescence des sondes peuvent ainsi être détectés par des techniques de fluoroscopie en temps réel.
Cheng Heping
Dirksen Robert
Groom Linda
Sheu Shey-Shing
Wang Wang
Ridout & Maybee Llp
University Of Rochester
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