C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 73/00 (2006.01) A61K 31/58 (2006.01) A61P 5/24 (2006.01)
Patent
CA 2120343
2120343 9403475 PCTABS00030 Compounds of formula (I), wherein: the symbol .... represents a single or a double bond; B is a bond or a straight or branched C1-C6 alkylene chain; R is hydrogen or C1-C4 alkyl; R1 is hydrogen, C1-C6 alkyl or benzyl; R2 is a) hydrogen, fluorine, C1-C6 alkyl, C5-C7 cycloalkyl or C6-C9 cycloalkylalkyl; or b) aryl or C7-C10 arylalkyl; R3 is a) hydrogen, fluorine or C1-C4 alkyl; or b) aryl or C7-C10 arylalkyl; R4 is hydrogen, fluorine, or is absent when Y is a double bond; R5 is hydrogen, fluorine or C1-C6 alkyl; and when Y is a single bond, A is hydrogen, fluorine or (i) wherein each of R6, R7 and R8 independently is hydrogen, fluorine or C1-C6 alkyl; and when Y is a double bond, A is a (ii) wherein each of R6 and R7 is independently hydrogen, fluorine or C1-C6 alkyl; with the proviso that at least one of the groups R, R1, R2, R3, R4, R5 or A contains at least one fluorine atom.
Di Salle Enrico
Nesi Marcella
Panzeri Achille
Pharmacia & Upjohn S.p.a.
Smart & Biggar
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