Fluorinated bis (hydroxymethyl) cyclobutyl purines and...

Details Fluorinated bis (hydroxymethyl) cyclobutyl purines and... Fluorinated bis (hydroxymethyl) cyclobutyl purines and...

C - Chemistry, Metallurgy

07

D

C07D 473/00 (2006.01) C07C 43/14 (2006.01) C07C 43/178 (2006.01) C07C 43/313 (2006.01) C07C 43/315 (2006.01) C07C 45/51 (2006.01) C07C 45/63 (2006.01) C07C 49/753 (2006.01) C07C 69/757 (2006.01) C07C 309/75 (2006.01) C07D 239/46 (2006.01) C07D 239/54 (2006.01) C07D 239/553 (2006.01) C07D 317/16 (2006.01) C07D 487/04 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2042931

GY18b ABSTRACT Antiviral activity is exhibited by compounds having the formula Image and its pharmaceutically acceptable salts wherein R1 is Image , GY18b Image , GY18b wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; R3 is fluoro, chloro, bromo, iodo, hydrogen, methyl, trifluoro- methyl, ethyl, n- propyl, 2-fluoroethyl, 2-chloro- ethyl, or Image wherein R4 is chloro, bromo, iodo, hydrogen, methyl or trifluoromethyl; R5 is alkyl; R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independently hydrogen, -PO3H2 or Image .

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