C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 13/04 (2006.01) A61K 31/7008 (2006.01) A61K 31/7024 (2006.01) A61K 49/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07H 13/02 (2006.01)
Patent
CA 2644917
The present invention relates to fluorine-containing monosaccharides that are useful for forming extracellular fluorinated glycoconjugates. Methods of forming extracellular fluorinated glycoconjugates comprise the steps of contacting a cell with a fiuorine- containing monosaccharide, and incubating the cell under conditions whereby the cell internalizes the fluorine-containing monosaccharide, or a derivative thereof, on the surface of the cell. The present invention also relates to the use of a fluorine-containing monosaccharide in cellular imaging using fluorine NMR. The invention additionally relates to the use of fluorine containing monosaccharides in the treatment of cancer and inflammatory disease.
La présente invention concerne des monosaccharides contenant du fluor qui sont utiles pour la formation de glycoconjugués fluorés extracellulaires. Des procédés de formation de glycoconjugués fluorés extracellulaires comprennent les étapes consistant à mettre en contact une cellule avec un monosaccharide contenant du fluor, et à faire incuber la cellule dans des conditions moyennant lesquelles la cellule internalise le monosaccharide contenant du fluor, ou un dérivé de celui-ci, sur la surface de la cellule. La présente invention concerne aussi l'utilisation d'un monosaccharide contenant du fluor en imagerie cellulaire en utilisant la RMN au fluor. L'invention concerne par ailleurs l'utilisation de monosaccharides contenant du fluor dans le traitement de cancers et de maladies inflammatoires.
D'alarcao Marc
Dafik Laila
Kumar Krishna
Borden Ladner Gervais Llp
Trustees Of Tufts College
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