Fluorinated derivatives of mevinic acids

Details Fluorinated derivatives of mevinic acids Fluorinated derivatives of mevinic acids

C - Chemistry, Metallurgy

07

D

167/244, 167/255

C07D 309/30 (2006.01) A61K 31/215 (2006.01) A61K 31/365 (2006.01) C07C 69/708 (2006.01) C07C 69/732 (2006.01)

Patent

CA 2040530

HX35 Abstract FLUORINATED DERIVATIVES OF MEVINIC ACIDS Compounds of the formula Image and pharmaceutically acceptable salts and tautomeric mixtures thereof possess activity as HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, Z is Image or Image ; R1 and R2 are each independently fluoro or hydrogen, except that at least one of R1 and R2 is fluoro; R3 is hydrogen, alkyl, cycloalkyl, aryl or arylalkyl; and R4 is hydrogen, alkyl, ammonium, alkylammonium, or alkali metal.

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