Fluorinated diaminobutane derivatives

Details Fluorinated diaminobutane derivatives Fluorinated diaminobutane derivatives

C - Chemistry, Metallurgy

07

D

260/549, 260/599

C07D 209/48 (2006.01) C07C 57/52 (2006.01) C07C 57/76 (2006.01)

Patent

CA 1173857

ABSTRACT OF THE DISCLOSURE Novel fluorinated diaminobutane derivatives are inhibitors of gramma-aminobutyric acid transminase and have the following general Formula 1:- Image Formula 1 wherein:- R1 represents hydrogen, C1-C6 alkyl or phenyl-C1-C4 alkyl; R2 represents hydrogen, C1-C6 alkyl, phenyl- C1-C4 alkyl, or R4, where R4 is as defined below; R3 represents hydrogen or, except when R2 represents R4, R4, where R4 is as defined below; each R4 independently represents C2-C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1-C4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal or an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; and p represents 1 or 2, and pharmaceutically acceptable acid addition salts thereof.

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