Fluorinated heteroaryls

Details Fluorinated heteroaryls Fluorinated heteroaryls

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/444 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) C07D 213/80 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07F 9/02 (2006.01)

Patent

CA 2729581

The present invention provides Formula (1A) XN O R 3 HN R 5 O R 4 R 2 R 1(1A) 5 compounds that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the glucokinase enzyme, where X, R 1, R 2, R 3, R 4, and R 5 are as described herein.

La présente invention porte sur des composés de formule (1A) XNOR3HNR5OR4R2R1 (1A) qui agissent comme activateurs de la glucokinase; sur des compositions pharmaceutiques de ces composés; et sur des méthodes de traitement de maladies, troubles ou états à médiation par l'enzyme glucokinase, où X, R1, R2, R3, R4 et R5 sont tels que définis présentement.

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