C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/407 (2006.01) A61K 31/41 (2006.01) A61K 31/4192 (2006.01) A61P 31/14 (2006.01) C07D 498/08 (2006.01)
Patent
CA 2719008
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: (I) which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
L'invention concerne des composés de la formule I ou des sels, des esters pharmaceutiquement acceptables ou des promédicaments de ceux-ci : (I) qui empêchent l'activité de la sérine protéase, en particulier l'activité de protéase NS3-NS4A du virus de l'hépatite C (VHC). En conséquence, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont également utiles en tant qu'agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés mentionnés ci-dessus pour l'administration à un sujet souffrant de l'infection du VHC. L'invention concerne également des procédés de traitement d'une infection par VHC chez un sujet en administrant une composition pharmaceutique comprenant les composés de la présente invention.
Gai Yonghua
Or Yat Sun
Wang Zhe
Enanta Pharmaceuticals Inc.
Torys Llp
LandOfFree
Fluorinated macrocyclic compounds as hepatitis c virus... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fluorinated macrocyclic compounds as hepatitis c virus..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorinated macrocyclic compounds as hepatitis c virus... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1728218