Fluorinated polyenes

Details Fluorinated polyenes Fluorinated polyenes

C - Chemistry, Metallurgy

07

C

260/361, 260/552

C07C 69/65 (2006.01) C07C 29/147 (2006.01) C07C 33/48 (2006.01) C07C 41/26 (2006.01) C07C 43/178 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/29 (2006.01) C07C 45/45 (2006.01) C07C 47/277 (2006.01) C07C 59/64 (2006.01) C07D 307/38 (2006.01) C07D 307/42 (2006.01) C07D 307/54 (2006.01) C07D 333/06 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1123442

ABSTRACT Compounds of the formula Image wherein R is a moiety of one of the formulae Image Image and wherein one of R1 and R2 is fluorine and the other is hydrogen; R3 is formyl, hydroxy- methyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, carbamoyl, mono(lower alkyl)-car- bamoyl or di(lower alkyl)carbamoyl; at least one of R4, R5 and R7 is halogen and the others are hydrogen or lower alkyl; R6 is lower alkyl or lower alkoxy; R8 and R 11 each are lower alkyl; R9 is hydrogen or lower alkyl; and R10 is oxygen or sulphur; with the proviso that when R3 is alkoxycarbonyl and R10 is sulphur, the compound is all trans; or pharmaceutically acceptable salts thereof, are useful in the treatment of tumors and acne. They are prepared by Wittig or Horner reaction from an ali- phatic and an aromatic component.

331353

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