Fluorinated trienes and their use as rxr modulators

Details Fluorinated trienes and their use as rxr modulators Fluorinated trienes and their use as rxr modulators

C - Chemistry, Metallurgy

07

C

C07C 59/64 (2006.01) A61K 31/192 (2006.01) A61P 3/00 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2438874

The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.

L'invention concerne un procédé de modulation de l'activité du récepteur de X rétinoïdes chez un mammifère, de nouveaux composés et compositions pharmaceutiques servant à moduler l'activité du récepteur de X rétinoïdes chez un mammifère, ainsi que des procédés de préparation de composés modulant l'activité du récepteur de X rétinoïdes chez un mammifère. Ces composés sont représentés par la formule (I), ces composés sont des agents efficaces de sensibilisation à l'insuline et ne présentent pas les effets secondaires indésirables d'augmentation des triglycérides ou de suppression de l'axe hormonal thyroïdien.

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