Fluorinated tripeptide hcv serine protease inhibitors

Details Fluorinated tripeptide hcv serine protease inhibitors Fluorinated tripeptide hcv serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/395 (2006.01) A61P 31/14 (2006.01) C07D 207/16 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2708150

The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: (I) which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Cette invention concerne des composés de formule I, un sel, un ester pharmaceutiquement acceptable, ou son promédicament : (I) qui inhibe l'activité de la sérine protéase, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Les composés de l'invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont également utiles comme agents antiviraux. L'invention concerne également des compositions pharmaceutiques comprenant les composés susmentionnés à administrer chez un sujet infecté par le VHC. L'invention concerne par ailleurs des procédés de traitement d'une infection à VHC chez un sujet en lui administrant une composition pharmaceutique comprenant les composés de l'invention.

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