Fluorinated vitamin d3 derivative

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 401/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2141652

This invention is for 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne- cholecalciferol, which can be further characterized by the formula: Image and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis. It can be prepared by removing the silyl protecting groups from a corresponding compound with silyl protected hydroxy groups.

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