Fluorination with hydrogen fluoride

Details Fluorination with hydrogen fluoride Fluorination with hydrogen fluoride

C - Chemistry, Metallurgy

07

D

260/295

C07D 213/61 (2006.01) C07D 213/84 (2006.01)

Patent

CA 2024032

ABSTRACT Fluoropyridine compounds having a fluoro substituent in at least one of the 2-, 4-, and 6- -positions are prepared by treatment of an appropriate 2-, 4-, or 6-chloropyridine compound with excess hydrogen fluoride in a dipolar, aprotic solvent at an elevated temperature and super-atmospheric pressure. Thus, 3,5-dichloro-2,4,6-trifluoropyridine is prepared by heating a mixture of pentachloropyridine, N-methyl-2- -pyrrolidinone, and hydrogen fluoride at about 220°C and about 900 kiloPascals of pressure.

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