Fluorine comprising dipeptides as inhibitors against human...

Details Fluorine comprising dipeptides as inhibitors against human... Fluorine comprising dipeptides as inhibitors against human...

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 38/05 (2006.01) C07D 471/04 (2006.01) C07F 9/547 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2139421

The present invention relates to certain novel amide derivatives of formula (I) which are pyrido [3,4-d] pyrimidin-7-ylaceta-mides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

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