C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/147, 260/581
C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07J 9/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 1297869
ABSTRACT OF THE DISLCOSURE There are disclosed novel derivatives of 26,26,26,27,27,27-hexafluorovitamin D3 having fluorine atom at the 23- and/or 24-position which have an excellent pharmacological activity and a process for production thereof. The novel compounds are represented by the general formula: Image wherein R1' denotes a hydrogen atom, a hydroxyl group or a protected hydroxyl group, R2 denotes a hydrogen atom or a protecting group for hydroxyl group, R3 denotes a hydrogen atom, a fluorine atom, a hydroxyl group or a protected hydroxyl group and R4 and R4' each denotes a hydrogen atom, or one of them denotes a hydrogen atom and the other denotes a fluorine atom, hydroxyl group or a protected hydroxyl group or R4 and R4' are combined to denote an oxo group, with a proviso that at least one of R3, R4 and R4' denotes a fluorine atom. The process for production thereof comprises subjecting to thermal isomerization a compound represented by the general formula: Image wherein R1', R2, R3, R4 and R4' are the same as defined above, to thermal isomerization and optionally further to deprotection reaction.
549562
Hamma Noritaka
Katsumata Takashi
Nishizawa Toshio
Saito Yoshikazu
Hamma Noritaka
Katsumata Takashi
Marks & Clerk
Nishizawa Toshio
Saito Yoshikazu
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