Fluoro-amide derivatives

Details Fluoro-amide derivatives Fluoro-amide derivatives

C - Chemistry, Metallurgy

07

K

167/103.05, 530/

C07K 5/065 (2006.01) A61K 38/05 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2016209

ICIAM 35262 ABSTRACT "FLUORO-AMIDE DERIVATIVES" The present invention relates to certain fluoro-amide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated, including treatment of tissue degenerative diseases such as pulmonary emphysema. The invention also includes intermediates useful in the synthesis of these fluoro- amide derivatives, processes for preparing them, pharmaceutical compositions containing such peptide derivatives and methods for their use.

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