Fluoro-carbon emulsion enhancement agent for high intensity...

A - Human Necessities – 61 – K

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Details

A61K 41/00 (2006.01) A61K 9/127 (2006.01) A61K 47/12 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01) A61K 47/44 (2006.01) A61N 7/00 (2006.01)

Patent

CA 2593644

The present invention discloses a fluoro-carbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2µm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100°C, and the amount of the core material in the enhancement agent is 5-200ml/L. The fluoro-carbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment. Eventually, the ability of clinical HIFU treatment to ablate tumor cells can be significantly improved. Accordingly, the present invention discloses use of a fluoro-carbon emulsion enhancement agent for HIFU treatment during HIFU treatment.

La présente invention décrit un adjuvant d'émulsions au fluorocarbure pour un traitement HIFU, qui peut augmenter le dépôt d'énergie dans les régions cibles pendant le traitement. L'adjuvant comprend une phase discontinue se composant d'un noyau encapsulé par un matériau formant un film et une phase continue se composant d'un milieu aqueux, dans lequel la phase discontinue est bien distribuée dans la phase continue ; la taille des particules de la phase discontinue est de 0,1-2 µm ; la quantité de matériau formant un film dans l'adjuvant est de 0,1-100 g/L ; le matériau de noyau utilisé est un liquide qui réalise la transition de phase liquide-gaz à 38-100 °C et qui est incorporé dans l'adjuvant à raison de 5-200 ml/L. L'adjuvant d'émulsions au fluorocarbure pour traitement HIFU est capable d'améliorer l'environnement acoustique des régions cibles de manière remarquable, augmentant le dépôt d'énergie dans les tissus cibles pendant le traitement HIFU et en conséquence améliorant de manière significative l'effet de détérioration des cellules tumorales pendant un traitement HIFU clinique. La présente invention décrit aussi l'utilisation d'un adjuvant de ce type dans un traitement par HIFU.

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