C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
167/182, 260/208
C07H 15/252 (2006.01) A61K 31/70 (2006.01) C07C 50/38 (2006.01) C07D 303/10 (2006.01) C07D 303/32 (2006.01) C07D 317/26 (2006.01)
Patent
CA 2029715
NEW FLUORO-NAPHTHACENEDIONES, THEIR GLYCOSILATED DERIVATIVES AND THEIR MANUFACTURE PROCEDURES. ABSTRACT New 7-substituted fluoro-2.beta.-acetyl-2.alpha.,4.alpha.,5,12- -tetrahydroxy-1,2,3,4 tetrahydro-6,11-naphthacenediones having the general formula I: Image where X is a hydrogen atom, or a hydroxyl group, R and R1, which cannot be equal, are a hydrogen atom or a fluorine atom; R2 can be a hydrogen atom or a hydroxyl group or an alkoxy group. These fluoro-naphthacene- diones can be useful for obtaining new derivatives which show a different reactivity of the 2.alpha. hydroxyl, in particular new anthracyclines.
Arcamone Federico
Giolitti Alessandro
Guidi Antonio
Pasqui Franco
Pestellini Vittorio
A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Fetherstonhaugh & Co.
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