C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/235.01
C07D 307/935 (2006.01) C07D 307/937 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1208634
ABSTRACT Compounds of the formula Image I wherein one of the double bonds indicated by broken lines is present in 4,5 or 5,6-position, R is hydrogen or lower alkyl, R1 is methyl, hydrogen or hydroxy; R2 is hydrogen, methyl or fluoro; and R21 is hydrogen, fluoro, trifluoromethyl or methyl; with the proviso that when R21 is trifluoromethyl, R2 is hydrogen or methyl, their pharmaceutically acceptable salts, optical anti- podes or racemates are useful as anti-secretory agents, anti-hype-tensives, anti-ulcerogenic agents and blood platelet aggregation inhibiting agents. They can be prepared from compounds of the formula Image II
397775
Holland George W.
Maag Hans
Rosen Perry
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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