C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2727146
This invention concerns fluorinated 3,4-di- aryl-4,5-dihydro-1H-pyrazole-1-carboxamidine derivatives as cannabinoid-CB1 receptor antagonists, methods for preparing these compounds, novel intermediates useful for the synthesis of said compounds, methods for the preparation of these intermediates, pharmaceutical compositions containing one or more of these dihydropyrazole derivatives as active ingredient, as well as the use of these pharmaceutical compositions for the treatment of obesity and obesity-related cardiovascular disorders, drug addiction, cognition deficits, liver fibrosis and inflammatory disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
La présente invention concerne des dérivés de 3,4-diaryl-4,5-dihydro-1H-pyrazole-1-carboxamidine fluorés comme antagonistes des récepteurs cannabinoïdes CB1, des procédés permettant de préparer ces composés, de nouveaux intermédiaires utiles pour la synthèse desdits composés, des procédés de préparation de ces intermédiaires, des compositions pharmaceutiques contenant un ou plusieurs de ces dérivés de la dihydropyrazole comme principe actif, ainsi que lutilisation de ces compositions pharmaceutiques pour le traitement de lobésité et des troubles cardiovasculaires liés à lobésité, de la toxicomanie, des troubles cognitifs, de la fibrose du foie et des troubles inflammatoires. Les composés ont la formule générale (I) dans laquelle les symboles ont les significations données dans la description.
Lange Josephus H. M.
Van Vliet Bernard J.
Abbott Healthcare Products B.v.
Fetherstonhaugh & Co.
LandOfFree
Fluoro-substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fluoro-substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluoro-substituted... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1887285