Fluoro-substituted adamantane derivatives

Details Fluoro-substituted adamantane derivatives Fluoro-substituted adamantane derivatives

C - Chemistry, Metallurgy

07

C

C07C 233/58 (2006.01) A61K 31/19 (2006.01) A61K 31/21 (2006.01) C07C 53/138 (2006.01) C07C 61/135 (2006.01) C07C 69/00 (2006.01) C07C 69/753 (2006.01) C07C 211/38 (2006.01) C07C 233/08 (2006.01)

Patent

CA 2234319

Disclosed are the fluoro-substituted adamantane derivatives of the formula (see fig. I) and to pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are as defined herein. Preferably R1 is -CO2H or -NH2 and R2, R3 and R4 are each fluoro. Disclosed also is a pharmaceutical composition for treating neurological disorders, such as memory loss and Parkinson's disease, and bacterial and viral infections, comprising a therapeutically effective amount of a compound of formula 1 or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.

L'invention porte sur des dérivés de substitution fluorés d'adamantane, de formule (voir fig. I) et à des sels de ces dérivés, de qualité pharmaceutique, où R1, R2, R3 et R4 correspondent aux définitions données ici. Il est préférable que R1 soit -CO2H ou -NH2 et que R2, R3 et R4 soient chacun un fluor. L'invention présente également une composition pharmaceutique pour le traitement de troubles neurologiques, comme la perte de mémoire ou la maladie de Parkinson, ainsi que des infections bactériennes et virales; cette composition renferme une quantité thérapeutique efficace d'un composé de formule 1 ou d'un sel de ce dernier de qualité pharmaceutique, avec un véhicule de qualité pharmaceutique.

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