C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 239/48 (2006.01) C07D 407/12 (2006.01)
Patent
CA 2758614
The present invention relates to compounds of formula (I) wherein AA, R2 to R7 and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as selective inhibitors of JAK3 over JAK2 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.
La présente invention porte sur des composés représentés par la formule (I) : dans laquelle AA, R2 à R7 et X1 à X3 présentent la signification telle qu'indiquée dans la description et les revendications. Lesdits composés sont utiles en tant qu'inhibiteurs sélectifs de JAK3 par rapport à JAK2 pour le traitement ou la prévention de troubles immunologiques, inflammatoires, auto-immuns, allergiques et de maladies à médiation immunologique. L'invention porte également sur des compositions pharmaceutiques renfermant lesdits composés, sur la préparation de tels composés, ainsi que sur leur utilisation en tant que médicaments.
Harrison Richard John
Hobson Andrew
Ramsden Nigel
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cellzome Limited
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