C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/75 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/44 (2006.01) C07C 235/56 (2006.01) C07C 255/60 (2006.01) C07D 213/89 (2006.01)
Patent
CA 2165192
Compounds of formula (I), in which one of the substituents R1 or R2 stands for hydrogen, 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or totally or partially fluorine-substituted 1-4C-alkoxy, and the other stands for totally or partially fluorine-substituted 1-4C-alkoxy, and R3 stands for phenyl, pyridyl, R31, R32 and R33- substituted phenyl or R34, R35, R36 and R37- substituted pyridyl, in which R31 stands for hydroxy, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino; R32 stands for hydrogen, hydroxy, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy; R33 stands for hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy; R34 stands for hydroxy, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C- alkoxycarbonyl or amino; R35 stands for hydrogen, halogen, amino or 1-4C-alkyl; R36 stands for hydrogen or halogen; and R37 stands for hydrogen or halogen. These compounds constitute new effective bronchotherapeutic drugs.
L'invention concerne des composés de la formule (I) qui sont de nouveaux agents thérapeutiques efficaces pour les maladies bronchiques, formule dans laquelle un des substituants R1 et R2 désigne hydrogène, alcoxy 1-6C, cycloalcoxy 3-7C, cycloalkylméthoxy 3-7C, benzyloxy ou alcoxy 1-4C substitué en totalité ou partiellement par fluor, et R3 désigne phényle, pyridyle, phényle substitué par R31, R32 et R33 ou pyridyle substitué par R34, R35, R36 et R37, R31 désignant hydroxy, halogène, cyano, carboxyle, trifluorométhyle, alkyle 1-4C, alcoxy 1-4C, alcoxy-1-4C-carbonyle, alkyle 1-4C-carbonyle, alkyle 1-4C-carbonyloxy, amino, mono ou dialkyle 1-4C amino ou alkyle 1-4C-carbonylamino, R32 désignant hydrogène, hydroxy, halogène, amino, trifluorométhyle, alkyle 1-4C ou alcoxy 1-4C, R33 désignant hydrogène, halogène, alkyle 1-4C ou alcoxy 1-4C, R34 désignant hydroxy, halogène, cyano, carboxyle, alkyle 1-4C, alcoxy 1-4C, alcoxycarbonyle 1-4C ou amino, R35 désignant hydrogène, halogène, amino ou alkyle 1-4C, R36 désignant hydrogène ou halogène et R37 désignant hydrogène ou halogène.
Fetherstonhaugh & Co.
Nycomed Gmbh
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