Fluorogenic enzyme substrates and methods of preparation

Details Fluorogenic enzyme substrates and methods of preparation Fluorogenic enzyme substrates and methods of preparation

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) C07D 239/91 (2006.01) C07F 9/6512 (2006.01) C07H 15/00 (2006.01)

Patent

CA 2506897

This invention relates to hydrolase fluorogenic substrates with improved cell permeability, methods for the preparation thereof, and methods of measuring activities of hydrolases, particularly in cell-based assays. The substrates easily diffuse into the cells, where they are enzymatically processed to yield photostable fluorescent products, and are particularly fitted for visualising enzyme-derived activities in cell-based assays.

L'invention concerne des substrats fluorogènes d'hydrolases à perméabilité cellulaire améliorée, leurs procédés de préparation, et des procédés pour mesurer l'activité des hydrolases, en particulier dans des essais à base de cellules. Lesdits substrats se diffusent facilement dans les cellules, dans lesquelles ils sont traités de manière enzymatique pour créer des produits fluorescents photostables, et les substrats conviennent, en particulier, à la visualisation des activités dérivées des enzymes dans des essais à base de cellules.

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