C - Chemistry – Metallurgy – 09 – B
Patent
C - Chemistry, Metallurgy
09
B
C09B 57/00 (2006.01) A61K 41/00 (2006.01) A61K 49/00 (2006.01) C07D 487/22 (2006.01) C07F 9/12 (2006.01) C07F 9/6561 (2006.01) C07H 15/26 (2006.01) C09B 11/26 (2006.01) C09B 47/04 (2006.01)
Patent
CA 2227212
Fluorogenic substrates susceptible of fluorescence emission and photosensitisation by enzyme transformation suitable for diagnosis and photodynamic treatment of tumours, consisting of fluorescent substances with photosensitisation activity, chemically modified with a group quenching the fluorescence and photosensitisation properties, the said quencher group being removable by the cell enzyme activity with restoration of the properties of fluorescence and photosensitisation activity of the original substance.
Substrats fluorogènes susceptibles d'émettre une fluorescence et de présenter une activité de photosensibilisation lorsqu'ils sont soumis à une transformation enzymatique, convenant au diagnostic et au traitement photodynamique des tumeurs, et composés de substances fluorescentes à activité de photosensibilisation, chimiquement modifiées au moyen d'un groupe qui inhibe les caractéristiques de fluorescence et de photosensibilisation, ce groupe pouvant être supprimé par l'activité enzymatique cellulaire, de sorte que la fluorescence et l'activité de photosensibilisation de la substance originale soient rétablies.
Baglioni Piero
Bottiroli Giovanni
Croce Anna Cleta
Monici Monica
Consiglio Nazionale Delle Ricerche
Ridout & Maybee Llp
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