C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
150/15.3
C12Q 1/37 (2006.01) C07K 7/06 (2006.01) G01N 33/533 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2029123
ABSTRACT In the present invention, continuous data acquisition of substrate hydrolysis by a protease enzyme is achieved through the use of a fluorescent peptide substrate, wherein the quantum yield of fluorescence increases upon proteolytic cleavage of the substrate. Incubation of a viral protease enzyme with the fluorogenic substrate results in a time- dependent increase in fluorescence intensity which is linearly related to the extent of substrate hydrolysis.
Krafft Grant A.
Matayoshi Edmund D.
Wang Gary T.
Abbott Laboratories
Goudreau Gage Dubuc
Krafft Grant A.
Matayoshi Edmund D.
Wang Gary T.
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