Fluorophores for encapsulation into liposomes

Details Fluorophores for encapsulation into liposomes Fluorophores for encapsulation into liposomes

C - Chemistry, Metallurgy

07

D

260/229, 167/43,

C07D 493/10 (2006.01) C07H 15/26 (2006.01) G01N 33/533 (2006.01) G01N 33/543 (2006.01) G01N 33/58 (2006.01)

Patent

CA 1295999

"FLUOROPHORES FOR ENCAPSULATION INTO LIPOSOMES" ABSTRACT The present invention provides novel fluorescein derivative compounds having fluorescence spectrum and quantum yield characteristics similar to those of fluorescein. The compounds are readily synthesized and purified and are readily soluble in water at self-quenching concentrations. Significantly, due to the presence of polar polyhydroxy group substituents and the absence of metal-chelating groups, these fluorescein derivatives are susceptible to minimal leakage across liposome membranes and have fluorescence characteristics minimally sensitive to the presence of metal ions. Compounds of the invention are thus exceptionally suitable for use in the development of highly storage stable liposome preparations to be employed in immunolytic assays involving human body fluid samples.

570160

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