C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/12 (2006.01) A61K 31/55 (2006.01) A61P 31/04 (2006.01) C07D 401/04 (2006.01)
Patent
CA 2756769
A molecular crystal form of (R)-(+)-7-(3-amino-2,3,4,5,6,7-hexahydro-1H-azepin- 1-yl)-1,4-dihydro-4-oxoquinoline-3 -carboxylic acid is characterized by at least one of: (a) an X-ray powder diffraction ("XRPD") spectrum that comprises peaks at 2.THETA. angles of 10.6, 15, 19.7, 21.1, and 22°~0.2 °; (b) a DSC melting peak at 288 °C; (c) a 13C NMR spectrum having peaks at 23.3, 27.7, 41.1, 54.5, 116.6, and 153.5 ppm; and (d) pKa values of 5.65 and 9.91.
La forme cristalline moléculaire d'acide (R)-(+)-7-(3-amino-2,3,4,5,6,7- hexahydro-lH-azépin-l-yl)-l,4-dihydro-4-oxoquinoline-3-carboxylique selon l'invention présente au moins une des caractéristiques suivantes : (a) un spectre de diffraction des rayons X sur poudres (« XRPD ») qui comprend des pics aux angles 2? de 10,6, 15, 19,7, 21,1, et 22° ± 0,2° ; (b) un pic de fusion DSC à 288°C ; (c) un spectre RMN 13C ayant des pics à 23,3, 27,7, 41,1, 54,5, 116,6, et 153,5 ppm ; et (d) des valeurs pKa de 5,65 et 9,91.
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
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