Fluorosugar derivatives of macrolides

Details Fluorosugar derivatives of macrolides Fluorosugar derivatives of macrolides

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2132457

Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), wherein n is 1 or 2; A and B are taken together and form =0 or A and B are taken separately and are each OH or A is OH and B is H; R1 is a fluoroglycosyl group; R2 is OH or a fluoroglycosyloxy group; and R3 is an alkyl or allyl group.

Macrolides de formule (I) et méthodes de traitement pour la résistance aux transplantations, aux infections fongiques et aux maladies auto-immunes, comme la polyarthrite rhumatoïde et le psoriasis, à l'aide de ces macrolides de formule I, où n est 1 ou 2; A et B pris ensemble forment =0, ou A and B pris séparément sont chacun OH, ou A est OH et B est H; R1 est un groupe fluoroglycosyle; R2 est OH ou un groupe fluoroglycosyloxy; enfin, R3 est un alkyle ou un allyle.

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