Flupirtine hydrochloride maleic acid cocrystal

Details Flupirtine hydrochloride maleic acid cocrystal Flupirtine hydrochloride maleic acid cocrystal

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/44 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) C07D 211/36 (2006.01)

Patent

CA 2738866

The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.

Linvention concerne des formes cristallines de flupirtine, notamment un co-cristal 1:1 dhydrochlorure de flupirtine et dacide maléique. La préparation et la caractérisation du co-cristal 1:1 dhydrochlorure de flupirtine et dacide maléique sont décrites. Linvention concerne également lutilisation thérapeutique du co-cristal dhydrochlorure de flupirtine et dacide maléique pour traiter des troubles du système nerveux, des troubles de la douleur et des troubles musculosquelettiques, ainsi que des compositions pharmaceutiques contenant le co-cristal.

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