Fmoc-l-leucine and derivatives thereof as ppar-gamma agonists

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

IPC codes

C07C 271/22 (2006.01) A61K 31/325 (2006.01) A61P 1/00 (2006.01) A61P 7/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Type

Patent

Patent number

CA 2415873

Description

The present invention relates to a method for treating or preventing a PPAR- .gamma. mediated disease or condition comprising administration of a therapeutically effective amount of FMOC-L-Leucine or derivatives thereof, of the formula I: Said method is particularly useful for treating or preventing anorexia, hyperlypidemia, insulin resistance, inflammatory diseases, cancer and sking disorders.

L'invention concerne un procédé destiné à traiter ou à prévenir une maladie ou un trouble induit par PPAR-.gamma.. Ce procédé comprend l'administration d'une quantité thérapeutiquement efficace de FMOC-L-Leucine ou des dérivés de celle-ci, de formule I. Ledit procédé est particulièrement utile pour traiter ou prévenir l'anorexie, l'hyperlipidémie, l'insulinorésistance, les maladies inflammatoires, le cancer et les affections cutanées.

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