Fo-1289 substance and its production

Details Fo-1289 substance and its production Fo-1289 substance and its production

C - Chemistry, Metallurgy

12

P

C12P 17/18 (2006.01) C07D 493/04 (2006.01) C12N 1/14 (2006.01)

Patent

CA 2127878

FO-1289 substance comprising FO-1289A substance, FO-1289B substance, FO-1289C substance and FO-1289D substance, which has inhibitory activity for acylcoenzyme A cholesterol acyltransferase is produced by culturing Aspergillus Sp. FO-1289. The substance is useful for treatment and prevention of a disease attributed by accumulation of cholesterol.

Une substance FO-1289, comprenant la substance FO-1289A, la substance FO-1289B, la substance FO-1289C et la substance FO-1289D, qui possède une activité inhibitrice sur l'acylCoA-cholestérol-acyl-transférase, est produite par culture d'Aspergillus Sp. FO-1289. La substance est utile pour le traitement et la prévention d'une maladie attribuable à l'accumulation de cholestérol.

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