Foamable vehicle and pharmaceutical compositions thereof

Details Foamable vehicle and pharmaceutical compositions thereof Foamable vehicle and pharmaceutical compositions thereof

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61P 17/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2610662

A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

L'invention concerne une composition pharmaceutique hygroscopique qui comprend au moins une substance hygroscopique à une concentration suffisante pour obtenir une valeur Aw d'au moins 0,9 et un agent anti-infectieux. L'invention concerne également un excipient pharmaceutique expansible qui comprend entre environ 50 % et environ 98 % d'un solvant polaire sélectionné dans le groupe comprenant un polyol et PEG ; entre 0 % et environ 48 % d'un solvant polaire secondaire ; entre environ 0,2 % et environ 5 % en poids d'un tensioactif ; entre environ 0,01 % et environ 5 % en poids d'au moins un agent polymère ; et un gaz propulseur liquéfié ou comprimé à une concentration comprise entre environ 3 % et environ 25 % en poids de la composition totale.

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