Foaming antacid suspension tablets

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61K 9/46 (2006.01) A61K 33/08 (2006.01) A61K 33/10 (2006.01) A61K 33/12 (2006.01) A61K 33/42 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2355627

The invention relates to antacid preparations comprising the following ingredients: (i) an acid binding active substance (Antacid) or a mixture of said active substances, (ii) a CO2 releasing effervescent mixture, (iii) a polymeric tenside as foaming agent or a mixture of said tensides, (iv) a swelling and gel-forming polymer or a mixture of said polymers and (v) optionally common adjuvants. The invention also relates to a method for the production of said antacid preparations. In a preferred embodiment, the antacid preparations are formulated in the form of a chewable tablet. The antacid preparations disclosed in the invention are suitable for symptomatic treatment of duodenal ulcer, gastric ulcer, heartburn and acid related gastric problems such as gastric hyperacidity.

L'invention concerne des préparations antiacides, caractérisées en ce qu'elles renferment les composants ci-après: (i) une substance active à liaison aux acides (antiacide), ou un mélange de telles substances actives, (ii) un mélange effervescent dégageant du CO¿2?, (iii) un tensioactif polymère en tant qu'agent moussant ou un mélange de tels tensioactifs, (iv) un polymère gonflant ou gélifiant, ou un mélange de tels polymères, et (v), éventuellement, des produits auxiliaires de type courant. L'invention concerne également un procédé de fabrication de telles préparations antiacides. Selon une forme d'exécution particulièrement préférée, la préparation antiacide est formulée sous la forme d'un comprimé à mâcher. Les préparations antiacides selon l'invention conviennent pour le traitement symptomatique de l'ulcère duodénal, de l'ulcère gastrique, ainsi que des aigreurs et des troubles gastriques dus aux acides, tels que l'hyperacidité gastrique.

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