Focused microarray and methods of diagnosing...

Details Focused microarray and methods of diagnosing... Focused microarray and methods of diagnosing...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/00 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2613290

Disclosed are methods for diagnosing chemotherapeutic drug resistance in a cancer cell sample by detecting an increase in the levels of expression of marker genes in the cancer cell sample as comp Ësd to the levels of expression of the same marker genes in a chemotherapeutic drug-sensitive cancer cell of the same tissue type. Also disclosed is a focused microarray device for diagnosis of chemotherapeutic drag resistance in cancer cells.

La présente invention concerne des procédés de diagnostic de résistance aux médicaments chimiothérapeutiques dans un échantillon de cellule cancéreuse, basés sur la détection d~une augmentation du taux d~expression de gènes marqueurs dans l~échantillon de cellule cancéreuse par rapport au taux d'expression de ces mêmes gènes marqueurs dans une cellule cancéreuse sensible aux médicaments chimiothérapeutiques relevant du même type de tissu. L~invention concerne également un dispositif à base de micromatrice d~ADN focalisée visant à diagnostiquer une résistance aux médicaments chimiothérapeutiques dans des cellules cancéreuses.

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