C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/25 (2006.01) G01N 33/82 (2006.01)
Patent
CA 2543860
The present invention provides methods for identifying improved folate antagonists. The improved folate antagonists identified by the methods of the invention have increased selectivity. The increased selectivity of the folate antagonists results in a reduced risk of adverse effects following treatment with the improved folate antagonists. The improved folate antagonists are identified based on their reduced binding affinity for at least one enzyme selected from glutathione synthase, pyruvate carboxylase, propionyl-CoA carboxylase, biotin carboxylase, acetyl-CoA carboxylase, and methylcrotonyl- CoA carboxylase. According to the invention, folate antagonists having reduced affinity for at least one enzyme selected from this group of enzymes are selected for the treatment of neoplastic hyperproliferative, and immune disorders.
L'invention concerne des méthodes pour identifier des antagonistes du folate améliorés, ces derniers présentant une sélectivité améliorée. La sélectivité améliorée engendre un risque réduit des effets secondaires du traitement grâce aux antagonistes de folate améliorés. Lesdits antagonistes sont identifiés sur la base de leur affinité de liaison réduite pour au moins une enzyme sélectionnée parmi la glutathione synthase, la pyruvate carboxylase, la propionyl-CoA carboxylase, la biotine carboxylase, l'acétyl-CoA carboxylase, et la méthylcrotonyl-CoA carboxylase. Selon l'invention, des antagonistes du folate présentant une affinité réduite à au moins une enzyme sélectionnée par le groupe des enzymes sont sélectionnés pour le traitement des troubles néoplasiques, hyperproliférants et immuns.
Serenex Inc.
Torys Llp
LandOfFree
Folate antagonists having improved selectivity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Folate antagonists having improved selectivity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Folate antagonists having improved selectivity will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1445712