Folate conjugates and complexes

Details Folate conjugates and complexes Folate conjugates and complexes

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) A61K 31/7088 (2006.01) A61K 38/43 (2006.01) A61K 38/46 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/22 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2553221

Disclosed are conjugates and complexes that include a folate receptor ligand and one or more therapeutic molecules, such as onconase or a variant thereof such as rapLR1. The conjugates and complexes may be useful as primary therapeutic agents, which may be administered with additional therapeutic or diagnostic agents. Also disclosed are kits that include the conjugates and complexes.

L'invention concerne des conjugués et complexes qui comprennent un ligand de récepteurs de folate et une ou plusieurs molécules thérapeutiques telles que l'onconase ou une variante de celle-ci telle que rapLR1. Les conjugués et complexes peuvent être utiles en tant qu'agents thérapeutiques primaires, qui peuvent être administrés avec des agents thérapeutiques ou diagnostiques supplémentaires. L'invention concerne aussi des kits qui comprennent ces conjugués et complexes.

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