Folding proteins

Details Folding proteins Folding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2182499

Nucleic acid encoding subunits of a polypeptide folding complex containing TCP-1 is useful in expression of the subunits for assembly of the complex in vitro or in vivo. The complex promotes folding of polypeptides, such as tubulin, e.g. following recombinant expression. The sequences share a high degree of homology but the C-terminii are sufficiently different to enable peptides with sequences derived therefrom to be used in obtaining antibodies specific for the various subunits, i.e. able to distinguish between them. The antibodies may be used in analysis and design of complexes able to fold different polypeptides.

L'acide nucléique codant les sous-unités d'un complexe de repliement de polypeptides qui contient TCP-1 est utile dans l'expression des sous-unités pour l'assemblage du complexe in vitro ou in vivo. Ledit complexe favorise le repliement de polypeptides tels que la tubuline, par exemple, à la suite d'une expression de recombinaison. Les séquences présentent en commun un degré d'homologie élevé, alors que les extrémités C sont suffisamment différentes pour permettre l'utilisation des peptides et de séquences dérivées de ces derniers dans la production d'anticorps spécifiques aux diverses sous-unités, c'est-à-dire capables de distinguer ces dernières. Lesdits anticorps peuvent être utilisés dans l'analyse et la conception de complexes capables de replier différents polypeptides.

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