Food material for promoting the differentiation of...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/47 (2006.01) A23K 1/16 (2006.01) A23L 1/305 (2006.01) A61K 38/00 (2006.01) A61P 19/08 (2006.01) C07K 2/00 (2006.01)

Patent

CA 2704144

Disclosed is an osteoblast differentiation promoting and osteoclast differentiation inhibiting agent which comprises a milk protein fraction having the following characteristics (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 75,000 to 85,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 13 to 15 wt% in the constitutional amino acid composition, and has a basic amino acid/acidic amino acid of 0.5 to 0.7; and (4) the milk protein fraction has an osteoblast differentiation promoting effect and an osteoclast differentiation inhibiting.

La présente invention concerne un agent qui favorise la différenciation d'un ostéoblaste et qui inhibe la différenciation d'un ostéoclaste, cet agent comprenant une fraction de protéine du lait qui présente les propriétés caractéristiques (1) à (4) telles que (1) la fraction de protéine du lait est dérivée du lait; (2) la fraction de protéine du lait est une fraction qui contient un constituant protéique ayant un poids moléculaire compris entre 75 000 et 80 000 Daltons; (3) dans la composition d'acides aminés du constituant de la fraction de protéine du lait, la teneur en acides aminés basiques est comprise entre 13 et 15% en poids et le rapport entre la quantité du ou des acides aminés basiques et la quantité du ou des acides aminés acides [acide(s) aminé(s) basique(s)/acide(s) aminé(s) acide(s)] se situe entre 0,5 et 0,7; et (4) la fraction de protéine du lait présente une activité favorisant la différenciation d'un ostéoblaste et inhibant la différenciation d'un ostéoclaste.

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